Rudi H. Ettrich
Dr. Rudi H. Ettrich is a higher education leader, scientist, and full professor with more than 20 years of experience in biomedical sciences and academic administration. He currently serves as President and Chief Executive Officer of Larkin University in Miami, Florida, where he also holds a faculty appointment in the College of Biomedical Sciences. In addition, he serves as a community-based adjunct professor in the Department of Cellular Biology and Pharmacology at the Herbert Wertheim College of Medicine at Florida International University.
Dr. Ettrich completed his undergraduate studies at Eberhard-Karls University in T眉bingen, Germany, and Charles University in Prague, Czech Republic. He earned his Ph.D. in Physical Chemistry at Charles University in 2001, specializing in the structural biology of protein complexes. Following a postdoctoral appointment at the Institute of Physical Biology at the University of South Bohemia (2002鈥2003), he joined the Academy of Sciences of the Czech Republic, where he became group leader in the Department of Structure and Function of Proteins and later head of the department.
In 2011, Dr. Ettrich became founding director of the Center for Nanobiology and Structural Biology of the Academy of Sciences in Nov茅 Hrady, South Bohemia, a research campus he helped establish and develop over more than a decade. In 2013, he was appointed Full Professor of Biophysics at the University of South Bohemia. He also founded and directed C4SYS, the Czech national distributed research infrastructure for systems biology, which since 2014 has been included among the priority research infrastructures on the Czech national research roadmap.
Dr. Ettrich鈥檚 research focuses on understanding fundamental biological processes through the integration of theoretical and experimental approaches in structural biology and biophysics. His work investigates the relationship between protein structure and function, dynamic molecular processes, and the interactions of cofactors and subunits within protein complexes. His research has contributed to understanding mechanisms underlying horizontal gene transfer, molecular origins of skeletal deformities, disease-related mutations, ion channel signaling in the immune system, and other molecular targets relevant to human health.
His research has received continuous support from national, European, and international funding agencies since 2001. Dr. Ettrich has authored more than 87 peer-reviewed publications, several book chapters, and numerous conference presentations. His work has been cited more than 2,600 times, and he has an H-index of 31.
Among his honors, Dr. Ettrich received the Otto Wichterle Award in 2006, presented by the Academy of Sciences of the Czech Republic to exceptionally promising young scientists. In 2010, he was nominated as a Princeton Global Scholar by the Department of Chemistry at Princeton University. In 2016, he was awarded a Senior Fulbright鈥揗asaryk Scholarship and served as a visiting professor at Nova Southeastern University鈥檚 College of Osteopathic Medicine, where he conducted research on skeletal bone deformities related to sulfur metabolism and PAPS-synthase.
Dr. Ettrich鈥檚 career combines scientific research, academic leadership, and institutional development, with a strong commitment to advancing biomedical science and higher education.
Education and Training
1993 B.Sc. (Vordiplom 鈥榩re-diploma鈥) in chemistry, Department of Chemistry, Eberhard-Karls-Universit盲t, T眉bingen, Germany
1998 Mgr. (corresponds to M.Sc.), Department of Physical Chemistry, Charles University, Prague Diploma thesis in physical and macromolecular chemistry: Chaperone-like Activity of Human Glycoproteins, supervisor: Prof. Z. Pavl铆膷ek
2002 Ph.D., Department of Physical Chemistry, Charles University, Prague; thesis: Human Haptoglobin: Structure and Interactions of a Tetrameric Chaperone-like Protein, supervisor: Prof. Z. Pavl铆膷ek
2002 RNDr., physical chemistry, Faculty of Sciences, Charles University, Prague
2006 Habilitation in biophysics 鈥 Habilitation defines the qualification to conduct self-contained university teaching and is the key for access to a professorship in Czech Republic
Employment and professional experience
12/2018 鈥 current Larkin University, FL, USA, President/CEO
09/2018 鈥 12/2018: Larkin University, FL, USA, interim CEO/President
08/2018 鈥 12/2018: College of Biomedical Sciences, Larkin University, FL, USA, Dean of the College and Professor.
12/2018 鈥 current: Department of Cellular Biology and Pharmacology, Wertheim College of Medicine, Florida International University 鈥 Community-based adjunct professor
08/2018 鈥 12/2019: Academy of Sciences of the Czech Republic (Institute of Microbiology), Prague, Czech Republic 鈥 senior research scientists
10/2016 鈥 4/2017: College of Osteopathic Medicine and College of Medical Sciences, NOVA Southeastern University, Fl, USA, visiting faculty, Fulbright-Masaryk Scholar
2006-2018, responsible for the Nove Hrady branch (now Center for Nanobiology and Structural Biology, Institute of Microbiology) of the Academy of Sciences of the Czech Republic, including European integration and graduate studies.
01/2016 鈥 8/2018: Center for Nanobiology and Structural Biology, Institute of Microbiology, Academy of Sciences of the Czech Republic, Nove虂 Hrady, Czech Republic – Head
6/2014 鈥 8/2018: C4SYS-Czech national research infrastructure for systems biology – Director
01/2011 鈥 12/2015: Institute of Nanobiology and Structural Biology, Global Change Research Center (from 01/2016 Center for Nanobiology and Structural Biology, Institute of Microbiology) Academy of Sciences of the Czech Republic, Nove虂 Hrady, Czech Republic – Director
07/2003 鈥 8/2018:聽 Center for Nanobiology and Structural Biology, Institute of Microbiology (formerly until 01/2016 Institute of Nanobiology and Structural Biology, Global Change Research Center, Academy of Sciences of the Czech Republic, until 12/2010 Institute of Systems Biology and Ecology ASCR), Nove虂 Hrady, Czech Republic – Head of Department of Structure and Function of Proteins and group leader.
07/2003 鈥 8/2018: lecturer at the University of South Bohemia, since 2006 Professor (associate) in biophysics (doc.), since 2013 full professor in biophysics (Prof.)
07/2002 鈥 07/2003: Institute of Physical Biology, University of South Bohemia, Ceske Budejovice – post-doc, area of research: computational biology
7/1993 鈥 8/1995: research assistant, Chemistry, Universita虉t Tu虉bingen, Germany
Publications:
1. Pavlicek Z., Ettrich R.*:Chaperone-like Activity of Human Haptoglobin. Chemical Papers(1998) 52, 309-310.
2. Pavlicek Z., Ettrich R.:Chaperone-like Activity of Human Haptoglobin: Similarity with alpha-Crystallin. Collect.Czech.Chem.Commun.(1999) 64 (4), 717-725.
3.Ettrich R.*, Melichercik M., Teisinger J., Ettrichova O., Krumscheid R., Hofbauerova K., Kvasnicka P., Schoner W. and Amler E.:Three-dimensional structure of the large cytoplasmic H4-H5 loop of Na+/K+-ATPase deduced by restraint-based comparative modeling shows only one ATP binding site.Journal of Molecular Modeling (2001) 7, 184-192.
4. Hofbauerova K., Kopecky Jr. V, Ettrich R.,Ettrichova O. and Amler E.: Secondary and Tertiary Structure of the Nucleotide-Binding Domain of the alpha-Subunit of Na+/K+-ATPase.Biopolymers(2002), 67, 242-246.
5. Kubala M., Hofbauerova K., Ettrich R., Kopecky Jr. V., Krumscheid R., Plasek J., Teisinger J., Schoner W. and Amler E.:Phe475and Glu446but not Ser445parcticipate in ATP-binding to the alpha -subunit of Na+/K+-ATPase.Biochem.Biophys.Res.Commun. (2002) 297, 154-159.
6. Ettrich R.,Brandt W., Kopecky Jr. V, Baumruk V., Hofbauerova K. and Pavlicek Z.:Behaviour of the Chaperone-Like Protein Haptoglobin under Heat Shock Conditions.Biological Chemistry(2002) 383 (10), 1667-1676.
7. Kopecky V. Jr., Ettrich R., Hofbauerova K. and Baumruk V.:Structure of human acid 飦 1-glycoprotein and its high-affinity binding site. Biochem.Biophys.Res.Commun.(2003) 300, 41-46.
8. Krumscheid R., Susankova K., Ettrich R., Teisinger J., Amler E. and Schoner W.:Localization of catalytic active sites in the large cytoplasmic domain of Na+/K+-ATPase.Annals of the New York Academy of Science(2003) 986, 242-244.
9. Vlachova V., Teisinger J., Susankova K., Lyfenko A., Ettrich R., Vyklicky L.:Functional role of C-terminal cytoplasmic tail of rat vanilloid receptor 1 (TRPV1). Journal of Neuroscience(2003), 23 (4), 1340-1350.
10.Ettrich R*.,Vlachova V., Teisinger J., Pavlicek J., Bezouska K., Kopecky Jr. V. and Stys D.:Molecular Modeling as a tool in molecular biology of membrane-bound receptors. Materials Structure(2003) 10 (3), 27-30.
11. Hofbauerova K., Kopecky Jr. V., Ettrich R.,Kubala M., Teisinger J., Ettrichova O. and Amler E.:Structural Biology on the sodium pump: a combined approach leading to a full characterization of the catalytic domain. Materials Structure(2003) 10 (3), 18-20 .
12. Hu拧谩kov谩 L., Herkommerov谩-Rajnochov谩 E., Seme艌uk T., Kuzma M., Rauvolfov谩 J., P艡ikrylov谩 V., Ettrich R.,Pl铆hal O., Bezou拧ka K., K艡en V.: Enzymatic discrimination of 2-acetamido-2-deoxy-D-mannopyranose-containing disaccharides using beta -N-acetylhexosaminidases.Advanced synthesis and catalysis(2003) 345 (6+7), 735-742.
13. Kubala M., Teisinger J., Ettrich R.,Hofbauerova K., Kopecky Jr. V., Baumruk V., Krumscheid R., Plasek J., Schoner W. and Amler E.:Eight amino acids forming the ATP recognition site of of Na+/K+-ATPase. Biochemistry(2003) 42 (21), 6446-6452.
14. Pavlicek J., Sopko B., Ettrich R.,Kopeck媒 Jr. V., Baumruk V., Man P., Havl铆膷kov谩 K., Vrback媒 M., K艡en V., Posp铆拧il M. and Bezou拧ka K.: Molecular Characterization of Binding of Calcium and Carbohydrates by an Early Activation Antigen of Lymphocytes CD69. Biochemistry(2003) 42 (31), 9295-9306. (RETRACTED)
15. Hofbauerova K., Kopecky Jr. V., Ettrich R.,Kubala M., Teisinger J. and Amler E.:ATP is stabilized by an stacking interaction within the binding site of Na+/K+-ATPase. Biochem.Biophys.Res.Commun. (2003) 306, 325-329.
16. Fialova P., Weignerova L., Rauvolfova J., Prikrylova V., Pisvejcova A., Ettrich R.,Sedmera P. and Kren V.:Hydrolytic and Transglycosylation Reactions of Unnatural N-Acyl Modified Substrates Catalysed by beta -N-Acetylhexosaminidases.
17. Sovova Z., Mazna P., Teisinger J., Stys D., Obsil T. and Ettrich R.*:A structural model of human MT2 melatonin receptor and its melatonin recognition site.Materials Structure(2004) 11 (1), 12-14 .
18.Pl铆hal O., Mihok L., Ettrich R., Man P., Havl铆膷ek V., Byrtusov谩 P., Pavlicek J. and Bezou拧ka K .:The isoforms of rat natural killer cell receptor NKR-P1 display distinct binding of complex saccharide ligands. Collect.Czech.Chem.Commun.(2004) 69 (3), 631-644. (RETRACTED)
19. Kopecky V. Jr., Ettrich R., Hofbauerova K. and Baumruk V.:Vibrational spectroscopy and computer modeling of proteins: solving structure of alpha1-acid glycoprotein . Spectroscopy: An International Journal (2004) 18 (2), 323-330.
20. Lansky Z., Kubala M., Ettrich R.,Kuty M., Plasek J., Teisinger J., Schoner W. and Amler E.:The hydrogen bond between Arg423 and Glu472 and another key residues Asp443, Ser477 and Pro489 are responsible for forming and a different positioning of TNP-ATP and ATP within the nucleotide binding site of Na+/K+-ATPase. Biochemistry(2004) 43 (26), 8303-8311.
21. Mazna P., Obsilova V., Jelinkova J., Balik A., Berka K., Sovova Z.,Ettrich R.Svoboda P., Obsil T. and Teisinger J.: Molecular modeling of human MT2 melatonin receptor: the role of Val204, Leu272 and Tyr298 in ligand binding. Journal of Neurochemistry(2004) 91 (4), 836-842.
22. Krumscheid R., Ettrich R., Sovova Z., Susankova K., Lansky Z., Hofbauerova K., Linnertz H., Teisinger J., Amler E. and Schoner W.:The phosphatase activity of the isolated H4-H5-loop of Na+/K+-ATPase resides outside its ATP binding site. Eur. J. Biochem(2004) 271, 3923-3936.
23. Fialova P., Namdjou DJ., Ettrich R.,Prikrylova V., Rauvolfova J., Krenek K., Kuzma M., Elling L., Bezou拧ka K. and Kren V.:Combined Application of Galactose Oxidase and b-N-Acetylhexosaminidase in the Synthesis of Complex Immunoactive N-Acetyl-d-galactosaminides. Advanced synthesis and catalysis(2005) 347 (7-8): 997-1006.
24. 艩tys D., Schoefberger W., Halbhuber Z., Ristvejova J., M眉ller M. and Ettrich R.*: Secondary structure estimation of recombinant psbHencoding a photosynthetic membrane protein of cyanobacterium Synechocystis sp. PCC 6803.Photosynthetica (2005) 43 (3): 421-424.
25. Fialova P., Carmona AT., Robina I., Ettrich R.,Sedmera P., P艡ikrylov谩 V., Hu拧谩kov谩 L., and K艡en V.: Glycosyl Azides 鈥 Novel Substrates for Enzymatic Transglycosylations.Thetrahedronletters(2005), 46: 8715-8718.
26.Ristvejova J, Kopecky V, Sovova Z, Balsera M, Arrelano JB, Green M. and Ettrich R*:Structure and Dynamics of the N-terminal Loop Region of PsbQ from Photosystem II of Spinacia oleracea studied by the Means of Molecular Modeling and Vibrational Spectroscopy.Biochem Biophys Res Commun (2006) 345: 1. 287-291
27. Carmona AT., Fialov谩 P. , K艡en V., Ettrich R., Mart铆nkov谩 L., Moreno-Vargas A. J., Gonz谩lez C. and Robina I.: Cyanodeoxy-Glycosyl derivatives as substrates for enzymatic reactionsEur. J. Org. Chem (2006)8. 1876-1885
28.Ettrich R.*,Kopeck媒 Jr., V.,Hofbauerov谩 K.,Baumruk V.,Pompach P.,Man P.,Havl铆膷ek V.,Pl铆hal O.,Jan Sklen谩艡 J.,Pi拧vejcov谩 A., Vladim铆r K艡en V. and Bezou拧ka K.: Structure of the dimeric N-glycosylated form of fungal beta-N-acetylhexosaminidase revealed by homology modeling, vibrational spectroscopy, biochemical and cross-linking studies. (2007) BMC Struct Biol 7: 05
29. Klara Susankova,Rudiger Ettrich,Ladislav Vyklicky,Jan Teisinger,Viktorie Vlachova(2007) 聽Contribution of the putative inner-pore region to the gating of the transient receptor potential vanilloid subtype 1 channel (TRPV1). 聽 J Neurosci 27: 28. 7578-7585
30. Zofie Sovova,Rudiger Ettrich* (2007) 聽Phylogenetic analysis of extrinstic proteins of Photosystem II. 聽 Materials Structure14: 1. 8-12
31. Jannette Carey,Jiri Brynda,Julie Wolfov谩,Rita Grandori,Tobias Gustavsson,R眉diger Ettrich,Ivana Kut谩 Smatanov谩(2007) 聽WrbA bridges bacterial flavodoxins and eukaryotic NAD(P)H:quinone oxidoreductases. 聽 Protein Sci 16: 10. 2301-2305
32. Jan Benedikt,Abdul Samad,Rudiger Ettrich,Jan Teisinger,Viktorie Vlachova(2009) 聽Essential role for the putative S6 inner pore region in the activation gating of the human TRPA1 channel. 聽 Biochimica et Biophysica Acta (BBA) 鈥 Molecular Cell Research 1793: 7. 1279-1288
33. Mikalai Lapkouski,Santosh Panjikar,Pavel Janscak,Ivana Kuta Smatanova,Jannette Carey,R眉diger Ettrich*,Eva Csefalvay(2009) 聽Structure of the motor subunit of type I restriction-modification complex EcoR124I. 聽 Nat Struct Mol Biol 16: 1. 94-95
34. J Kohoutov谩,I Kut谩 Smatanov谩,J Brynda,M Lapkouski,J L Revuelta,J B Arellano,R Ettrich*(2009) 聽Crystallization and preliminary crystallographic characterization of the extrinsic PsbP protein of photosystem II from Spinacia oleracea. 聽 Acta Crystallogr Sect F Struct Biol Cryst Commun 65: Pt 2. 111-115
35. Julie Wolfova, Ivana Kuta Smatanova, Jiri Brynda, Jeroen R Mesters,Mikalai Lapkouski,Michal Kuty,Antonino Natalello,Neal Chatterjee,Sy-Yeu Chern,Erin Ebbel,Angela Ricci,Rita Grandori,R眉diger Ettrich*,Jannette Carey(2009) 聽Structural organization of WrbA in apo- and holo-protein crystals 聽 Biochimica et Biophysica Acta (BBA) 鈥 Proteins and Proteomics 1794: 9. 1288-1298
36. Rebecca Strawn, Milan Melichercik, Michael Green, Thomas Stockner, Jannette Carey, Rudiger Ettrich*(2010) 聽Symmetric allosteric mechanism of hexameric Escherichia coli arginine repressor exploits competition between L-arginine ligands and resident arginine residues 聽 PLOS Computational Biology 6: 6. e1000801
37. Natallia Kulik, Lenka Weignerov谩, Tom谩拧 Filipi, Petr Pompach, Petr Nov谩k, Hynek Mr谩zek, Krist媒na Sl谩mov谩, Karel Bezou拧ka, Vladim铆r K艡en,R眉diger Ettrich*(2010) 聽The 伪-galactosidase type A gene aglA from Aspergillus niger encodes a fully functional 伪-N-acetylgalactosaminidase 聽Glycobiology20: 11. 1410-1419.
38. Krist媒na Sl谩mov谩, Radek Ga啪谩k, Pavla Bojarov谩, Natallia Kulik, Rudiger Ettrich, Helena Pelantov谩, Petr Sedmera, Vladim铆r K艡en (2010) 聽4-Deoxy-substrates for beta-N-acetylhexosaminidases: how to make use of their loose specificity 聽 Glycobiology20: 8. 1002-1009.
39. R Strawn, T Stockner, M Melichercik, L Jin, W 鈥 F Xue, J Carey, R Ettrich*(2011) 聽CHAPTER FIVE: Synergy of molecular dynamics and isothermal titration calorimetry in studies of allostery. 聽 In: Methods in Enzymology, Biothermodynamics, Part D Volume 492 Edited by:Michael L. Johnson, Jo M. Holt , Gary K. Ackers. pages 151-189 Academic Press 鈥 Elsevier Publishing Company, ISBN: 978-0-12-386003-3
40. M Horni膷谩kov谩, J Kohoutov谩, J Schlagnitweit, C Wohlschlager, R Ettrich, R Fiala, W Schoefberger, N M眉ller(2011) 聽Backbone assignment and secondary structure of the PsbQ protein from Photosystem II 聽 Biomolecular NMR Assignments 5: 2. 169-175.
41. P Bojarova, K Slamova, K Krenek, R Gazak, N Kulik, R Ettrich, H Pelantova, M Kuzma, S Riva, D Adamek, K Bezouska, V Kren(2011) 聽Charged hexosaminides as new substrates for 尾-N-acetyl-hexosaminidase catalyzed synthesis of immunomodulatory disaccharides 聽 Advanced Synthesis & Catalysis 353: 2409-2420.
42. 沤ofie Sovov谩, Vladim铆r Kopeck媒 Jr, Tom谩拧 Pazderka, Kate艡ina Hofbauerov谩, Daniel Rozbesk媒, Ond艡ej Van臎k, Karel Bezou拧ka,R眉diger Ettrich*(2011) 聽Structural analysis of natural killer cell receptor protein 1 (NKR-P1) extracellular domains suggests a conserved long loop region involved in ligand specificity Journal of Molecular Modeling 17: 6. 1353-1370.
43. Morteza Khabiri, Azadeh Nikouee, Lukasz Cwiklik, Stephan Grissmer, R眉diger Ettrich*(2011) 聽Charybdotoxin unbinding from the mKv1.3 potassium channel: A combined computational and experimental study Journal of Physical Chemistry B 115: 39. 11490鈥11500.
44. Ryslava, Helena, Kalendova, Alzbeta, Doubnerova, Veronika, Skocdopol, Premysl, Hodkova, Anna, Kukacka, Zdenek, Slamova, Kristyna, Bojarova, Pavla, Pompach, Petr, Kumar, Vinay, Kulik, Natallia, Ettrich, Rudiger, Kren, Vladimir, Bezou拧ka, Karel(2011) 聽Enzymatic characterization and molecular modeling of an evolutionarily interesting fungal beta-N-acetylhexosaminidase FEBS Journal 278: 2469-2484.
45. Jana Jir谩skov谩-Van铆膷kov谩, Rudiger Ettrich, Barbora Vorlov谩, Hillary Hoffman, Martin Lep拧铆k, Petr Jansa, Jan Konvalinka (2011) 聽Inhibition of Human Serine Racemase, an Emerging Target for Medicinal Chemistry Current Drug Targets 12: 7. 1037-1055.
46. Ondrej Kaplan, Karel Bezouska, Ondrej Plihal, Rudiger Ettrich, Natallia Kulik, Ondrej Vanek, Daniel Kavan, Oldrich Benada, Anna Malandra, Ondrej Sveda, Alicja B Vesela, Anna Rinagelova, Kristyna Slamova, Maria Cantarella, Jurgen Felsberg, Jarmila Duskova, Jan Dohnalek, Vladimir Kren, Ludmila Martinkova (2011) 聽Heterologous expression, purification and characterization of nitrilase from Aspergillus niger K10 聽 BMC Biotechnology 11: 2
47. Abdul Samad, Lucie Sura, Jan Benedikt, Rudiger Ettrich, Babak Minofar, Jan Teisinger, Viktorie Vlachova(2011) 聽The C-terminal basic residues contribute to the chemical and voltage-dependent activation of TRPA1 Biochemical Journal 433 (1): 197-204.
48. Azadeh Nikouee, Morteza Khabiri, Stephan Grissmer, R眉diger Ettrich*(2012) 聽Charybdotoxin and margatoxin acting on the human voltage-gated potassium channel hKv1.3 and its H399N mutant: An experimental and computational comparison Journal of Physical Chemistry B, 116 (17): 5132-5140.
49. Vladimir Kopecky Jr, Jaroslava Kohoutova, Mikalai Lapkouski, Katerina Hofbauerova, Zofie Sovova, Olga Ettrichov谩, Sergio Gonz谩lez-P茅rezc, Alexandr Dulebo, David Kaftan, Ivana Kuta Smatanova, Jose L Revuelta, Juan B Arellano, Jannette Carey, Rudiger Ettrich*(2012) 聽Raman spectroscopy adds complementary detail to the high-resolution x-ray crystal structure of photosynthetic PsbP from Spinacia oleracea聽 PLOS One7 (10): e46694
50. Alexander Dulebo, R眉diger Ettrich, Rudolf Lucas, David Kaftan(2012) 聽A Computational Study of the Oligosaccharide Binding Sites in the Lectin-Like Domain of Tumor Necrosis Factor and TIP Peptide. Current Pharmaceutical Design 18 (27): 4236-4243.
51. Iryna Kishko, Balasubramanian Harish, Vasilina Zayats, David Reha, Brian Tenner, Dhananjay Beri, Tobias Gustavsson, R眉diger Ettrich*, Jannette Carey(2012) 聽Biphasic kinetic behavior of聽FMN-dependent NAD(P)H:quinone oxidoreductase WrbA from E. coli 聽PLOS One 7 (8): e43902
52. Vasilina Zayats, Abdul Samad, Babak Minofar, Katherine Roelofs, Thomas Stockner, Rudiger Ettrich(2013) 聽Regulation of the transient receptor potential channel TRPA1 by its N-terminal ankyrin repeat domain Journal of Molecular Modeling,聽19:聽聽4689鈥4700.
53. Morteza Khabiri, Babak Minofar, Jan B艡ezovsky, Ji艡铆 Damborsk媒, Rudiger Ettrich*(2013) 聽Interaction of Organic Solvents with Protein Structures at Protein-Solvent InterfaceJournal of Molecular Modeling, 19: 4701鈥4711.
54. Veronika 艩t臎p谩nkov谩, Morteza Khabiri, Jan Brezovsk媒, Anton铆n Pavelka, Babak Minofar, Rudiger Ettrich, Radka Chaloupkov谩, Ji艡铆 Damborsk媒(2013) 聽Expansion of tunnels and active-site cavities influence catalytic activity of haloalkane dehalogenases in organic co-solvents ChemBioChem, (in the section: Very Important Paper (VIP)), 聽14:聽聽890鈥897.
55.Daniel Rozbesk媒, 沤ofie Sovov谩, Julien Marcoux, Petr Man, R眉diger Ettrich, Carol V Robinson, Petr Nov谩k (2013) 聽Structural model of lymphocyte receptor NKR-P1C revealed by mass spectrometry and molecular modelling 聽 Analytical Chemistry 85: 3. 1597鈥1604.
56. Tana Koudelakova, Radka Chaloupkova, Jan Brezovsky, Zbynek Prokop, Martina Pavlova, Martin Hessler, Morteza Khabiri, Maryia Plevaka, Daryna Kulik, Ivana Kuta Smatanova, Pavlina Rezacova, Rudiger Ettrich,Uwe T Bornscheuer, Jiri Damborsky (2013) Engineering Enzyme Stability and Resistance to an Organic Cosolvent by Modification of Residues in the Access Tunnel Angewandte Chemie (International Edition) 52: 1959 鈥1963.
57.Iryna Kishko, Jannette Carey, Jiri Brynda, Richard Guerra, Olga Ettrichova, Zdenek Kukacka, Petr Novak, Michal Kuty, Ivana Kuta Smatanova,Rudiger Ettrich*, Mikalai Lapkouski* (2013) 聽1.2 脜-resolution crystal structure of E.coli WrbA holoprotein.Acta Crystallographica Section D: Biological Crystallography: Biological Crystallography 69: 9. 1748-1757.
58. Krist媒na Sl谩mov谩, Natallia Kulik, Martin Fiala, Jana Krejzov谩-Hofmeisterov谩, R眉diger Ettrich,Vladim铆r K艡en聽(2014)聽聽Expression, characterization and homology modeling of a novel eukaryotic GH84 尾-N-acetylglucosaminidase from Penicillium chrysogenum聽Protein Expression and Purification聽95:聽聽204鈥210.
59. D Sinha, K Shamayeva, V Ramasubramani, D Reha, V Bialevich, M Khabiri, N Milbar, A Guzanova, M Weiserova, E Csefalvay, J Carey, R Ettrich*聽(2014)聽聽Interdomain communication in the endonuclease/motor subunit of Type I restriction-modification enzyme EcoR124I聽Journal of Molecular Modeling聽20 (7):聽聽2334.
60. S K Pandey, D Reha, V Zayats, M Melichercik, J Carey, R Ettrich聽*(2014)聽聽Binding-competent states for L-arginine in E. coli arginine repressor apoprotein.聽Journal of Molecular Modeling聽20 (7):聽2330.
61. Jana Krejzov谩, Krist媒na Sl谩mov谩, Petr 艩imona, Lubica Kalachova, Natallia Kulik, Pavla Bojarov谩, Petr Marhol, Helena Pelantov谩, Josef Cva膷ka, R眉diger Ettrich, Vladim铆r K艡en聽(2014)聽Inhibition of GlcNAc-processing glycosidases by C-6-azido-NAG-thiazoline and its derivatives聽Molecules聽19:聽聽3471-3488.
62. David Reha, Balasubramanian Harish, Dhiraj Sinha, Zdenek Kukacka, James McSally, Olga Ettrichova, Petr Novak, Jannette Carey, R眉diger Ettrich聽(2014)聽聽Molecular dynamics comparison of E. coli WrbA apoprotein and holoprotein.聽Journal of Molecular Modeling,20 (9):聽2400.
63. Natallia Kulik, Kristyna Slamova, Rudiger Ettrich, Vladimir Kren (2015) Computational study of 尾-N-acetylhexosaminidase from Talaromyces flavus, a glycosidase with high substrate flexibility聽BMC Bioinformatics聽16 (1):聽聽28.
64. Vasilina Zayats, Thomas Stockner, Saurabh K Pandey, Katharina W枚rz, R眉diger Ettrich, Jost Ludwig(2015) A refined atomic scale model of the Saccharomyces cerevisiae K+-translocation protein Trk1p combined with experimental evidence confirms the role of selectivity filter glycines and other key residues.聽BBA-Biomembranes聽1848 (5):聽聽1183-1195.
65. Adriana Walnerov谩, Kousik Chandra, Petr Rathner, Michaela Horni膷谩kov谩, Judith Schlagnitweit, Jaroslava Kohoutov谩, R眉diger Ettrich, Norbert M眉ller (2015) Resonance assignment of PsbP an extrinsic protein from Photosystem II of Spinacia oleracea聽Biomolecular NMR Assignments聽9 (2):聽聽341鈥346.
66. Eva Csefalvay, Mikalai Lapkouski, Alena Guzanova, Ladislav Csefalvay, Tatjana Baikova, Igor Shevelev, Vitali Bialevich, Katsiaryna Shamayeva, Pavel Janscak, Ivana Kuta Smatanova, Santosh Panjikar, Jannette Carey, Marie Weiserova, R眉diger Ettrich*(2012) 聽Functional coupling of duplex translocation to DNA cleavage in a type I restriction enzyme 聽PLOS One, PLoS ONE聽10 (6):聽聽e0128700
67. Petr Rathner, Adriana Walnerova, Michaela Hornicakova, Christian Wohlschlager, Kousik Chandra, Jaroslava Kohoutova, R眉diger Ettrich, Reinhard Wimmer, Norbert Mueller(2015) Solution Structure of PsbQ from Photosystem II of Higher Plants聽聽PROTEINS: Structure, Function, and Bioinformatics聽83 (9):聽聽1677鈥1686.
68. Irene Frischauf, Vasilina Zayats, Michael Deix, Anna Hochreiter, Isaac Jardin Polo, Martin Muik, Barbara Lackner, Barbora Svobodova, Teresa Pammer, Monika Litvinukova, Amrutha Arumbakam Sridhar, Isabella Derler, Ivan Bogeski, Christoph Romanin, R眉diger Ettrich*, Rainer Schindl*聽(2015) A calcium accumulating region, CAR, in the Orai1 channel enhances Ca2+- permeation and SOCE-induced gene transcription聽Science Signaling聽8 (408):聽聽ra131
69. Vladim铆r Kopeck媒 Jr, R眉diger Ettrich, Tom谩拧 Pazderka, Kate艡ina Hofbauerov谩, David 艠eha, Vladim铆r Baumruk聽(2016)聽聽Influence of ligand binding on structure and thermostability of human alpha-1-acid glycoprotein聽Journal of Molecular Recognition聽29 (2):聽聽70鈥79.
70. Isabella Derler, Isaac Jardin, Peter B Stathopulos, Martin Muik, Marc Fahrner, Vaselina Zayats, Saurabh Pandey, Michael Poteser, Barbara Lackner, Marketa Absolonova, Klaus Groschner, R眉diger Ettrich, Mitsu Ikura, Christoph Romanin (2016) Cholesterol binding modulates Orai1 channel function聽Science Signaling聽9 (412):聽聽ra10.聽Jan 26.
71. Oksana Degtjarik, Ji艡i Brynda, Olga Ettrichova, Michal Kuty, Dhiraj Sinha, Ivana Kuta Smatanova, Jannette Carey, R眉diger Ettrich, David 艠eha (2016) Quantum calculations indicate effective electron transfer between FMN and benzoquinone in a new crystal structure of E. coli WrbA聽Journal of Physical Chemistry B, 120 (22):4867-4877.
72. Pavel Grinkevich, Iuliia Iermak, Nicholas A Luedtke, Jeroen R Mesters,Rudiger Ettrich*, Jost Ludwig (2016) pHluorin(GFP)-assisted expression, purification, crystallization and X-ray diffraction data analysis of C-terminal domain of HsdR subunit from E. coli type I restriction-modification system EcoR124I. Acta Crystallographica Section F, 72 (9): 672- 676.
73. Irene Frischauf, Monika Litvi艌ukov谩, Romana Schober, Vasilina Zayats, Barbora Svobodov谩, Daniel Bonhenry, Victoria Lunz, Sabrina Cappello, Laura Tociu, David Reha, Amrutha Stallinger, Anna Hochreiter, Teresa Pammer, Carmen Butorac, Martin Muik, Ivan Bogeski, R眉diger Ettrich, Christoph Romanin, Rainer Schindl (2017) Transmembrane helix connectivity in Orai1 controls two gates for calcium-dependent transcription Science Signaling 10 (507): eaao0358. (Cover story)
74. Bialevich V, Sinha D, Shamayeva K, Reha D, Guzanova A, Csefalvay E, Carey J, Weiserova M and Ettrich R.*(2017) The helical domain of the motor subunit of EcoR124I participates in ATPase activity and dsDNA translocation, PeerJ, Volume 2017, Issue 1, 2017, Article number聽e2887.
75. Marc Fahrner, Saurabh K Pandey, Martin Muik, Lukas Traxler, Carmen Butorac, Michael Stadlbauer, Vasilina Zayats, Ad茅la Krizova, Peter Plenk, Irene Frischauf, Rainer Schindl, Hermann J Gruber, Peter Hinterdorfer, R眉diger H Ettrich, Christoph Romanin, Isabella Derler (2018) Communication between N-terminus and Loop2 tunes Orai activation The Journal of Biological Chemistry 293: 1271-1285.
76. Dhiraj Sinha, Vitali Bialevich, Katsiaryna Shamayeva, Alena Guzanova, Alexandra Sisakova, Eva Csefalvay, Lumir Krejci, Jannette Carey, Marie Weiserova, R眉diger H Ettrich*(2018) A residue of motif III positions the helicase domains of motor subunit HsdR in restriction-modification enzyme EcoR124I,Journal of Molecular Modeling聽24 (7):聽聽176.
77. Pavel Grinkevich, Dhiraj Sinha, Iullia Iermak, Alena Guzanova, Marie Weiserova, Jost Ludwig, Jeroen R. Mesters, Rudi H Ettrich* (2018) Crystal structure of a novel domain of the motor subunit of the Type I restriction-modification system EcoR124 involved in complex assembly and DNA binding, The Journal of Biological Chemistry 293 (39): 15043-15054.
78. Saurabh Pandey, Daniel Bonhenry, Rudi H Ettrich(2019)聽Chapter 10: Ion Channel Simulations.In: Biomolecular Simulations in Drug Discovery聽Edited by: Francesco L. Gervasio, Vojtech Spiwok, Raimund Mannhold, Helmut Buschmann, J枚rg Holenz. 聽聽pages 247-280,聽Book Series: Methods and Principles in Medicinal Chemistry, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany,聽isbn:978-3-527-34265-5.
79. Daniel Bonhenry, Romana Schober, Tony Schmidt, Linda Waldherr, Rudi H Ettrich, Rainer Schindl (2019) Mechanistic insights into the Orai channel by molecular dynamics simulations Seminars in Cell & Developmental Biology 94 (October 2019): 50-58.
80. Romana Schober, Daniel Bonhenry, Victoria Lunz, Jinhui Zhu, Adela Krizova, Irene Frischau, Marc Fahrner, Linda Waldherr, Tony Schmidt, Isabella Derler, Peter B. Stathopulos, Christoph Romanin, Rudi H. Ettrich* and Rainer Schindl* (2019) Sequential activation of STIM1 links Ca2+ with luminal domain unfolding. Science Signaling 12: eaax3194.
81. Saurabh Kumar Pandey, Milan Melichercik, David 艠eha, Rudi H Ettrich* and Jannette Carey* (2020) Conserved Dynamic Mechanism of Allosteric Response to L-arg in Divergent Bacterial Arginine Repressors. Molecules 25 (9): 2247.
82. Tiffner A, Schober R, Hoeglinger C, Bonhenry D, Pandey S, Lunz V, Sallinger M, Frischauf I, Fahrner M, Lindinger S, Maltan L, Berlansky S, Stadlbauer M, Schindl R, Ettrich R, Romanin C, Derler I. (2020) CRAC channel opening is determined by a series of Orai1 gating checkpoints in the transmembrane and cytosolic regions. J Biol Chem 296: 100224. doi: 10.1074/jbc.RA120.015548.
83. Venkatachalam, KV and Ettrich, RH (2021) Role of aspartic acid residues D87 and D89 in APS kinase domain of human 3 ‘-phosphoadenosine 5 ‘-phosphosulfate synthase 1 and 2b: A commonality with phosphatases/kinases. Biochem Biophys Reports 28: 101155. doi: 10.1016/j.bbrep.2021.101155.
84. Strawn R, Murthy PS, Ettrich RH, Pelczer I and Carey J (2024) Symmetry of a partially-ligated state maintained by dynamics in a negatively cooperative system. Front. Biophys. 2:1359979. doi: 10.3389/frbis.2024.1359979
85. Rudi H. Ettrich, Joshua Caballero, Prashant Sakharkar, Sultan Ahmed, Traci Hurlston, Jayesh Parmar, Subrata Deb (2024) Evaluation of Agreement Between a Noninvasive Method for Real-Time Measurement of Critical Blood Values with a Standard Point-of-Care Device. PLOS One 19(6): e0304706. DOI: 10.1371/journal.pone.0304706
86. Venkatachalam, KV, Sinha D, Soha C and Ettrich, RH (2025) Structure/function of ATP sulfurylase domain of human 3鈥-phosphoadenosine 5鈥-phosphosulfate synthase (hPAPSS) Biochem Biophys Reports 41: 101892. DOI: 10.1016/j.bbrep.2024.101892
87. Adrian Calderon, Eric Harbinson, Rudi H. Ettrich*, Natalia Kulik* and Jannette Carey* (2025) An MD View of Ligand Binding. Molecules. 2025 Dec 6;30 (24):4678. doi: 10.3390/molecules30244678.
Selected Invited Talks
鈥淐omputational modeling of 3鈥- Phosphoadenosine 5鈥-phoshosulfate synthase PAPS鈥, Visegrad Symposium, Sopron, Hungary, June 20-23. 2023 (invited plenary lecture)
“Cation translocation in human ORAI channels” Vienna BioCenter, invited CAPSID seminar 12.12.2018 (hosted by Dr. Peggy Stolt-Bergner):
“Modulation of human ORAI1 channels: modeling and simulations鈥, 15th International Life Science Meeting, Krems, Austria, 18.4.2018, (invited plenary lecture)
“Cation translocation in human ORAI channels” Biomedical Center of the Slovak Academy of Sciences (hosted by Dr. Ivana Nemcovicova), 11.12.2018
鈥淢odulation of human ORAI1 channels: modeling and simulations鈥 at the conference Cell Physics 2017, October 11-13, 2017, Saarbruecken, Germany (invited plenary lecture)
鈥淐omputational modeling of 3鈥- Phosphoadenosine 5鈥-phoshosulfate synthase PAPS鈥, SOFLACS -Chemical Sciences Symposium 2017 organized by the South Florida Chapter of the American Chemical Society, Ft. Lauderdale, FL, USA, February 26, 2017 (invited plenary lecture)
鈥淚nterdomain communication in Type I restriction-modification enzymes鈥 at the conference MGMS (Molecular Graphics and Modeling Society) 鈥淓xploring Mechanisms in Biology: Theory and Experiment鈥, November 25-27, 2015, Biopolis, Singapore (invited lecture)
鈥淪tructure and function of the motor subunit of the EcoR124I restriction-modification complex鈥 at the conference 鈥淢odelling Interactions in Biomolecules VII鈥, 14-18 September 2015, Pruhonice, Prague, Czech Republic.(invited plenary lecture)篓
鈥淔unctional coupling of duplex translocation to DNA cleavage in a type I restriction enzyme鈥, University of Kent, Canterbury, UK, 20.10. 2015 (invited seminar)
鈥淲as binding of free amino acids an early innovation in the evolution of allostery?鈥 at the 鈥淚nternational Conference on Informatics & Integrative Biology (CIIB-2014)鈥 Bose Institute 16.12-19.12.2014, University of Calcutta.
鈥淐ombined computational and experimental studies鈥 at the 11th International Life Science Meeting, IMC FH KREMS, March 25-26, 2014. (invited lecture, conference fee and accommodation covered by the organizers)
鈥淔unctional coupling of duplex translocation to DNA cleavage in a type I restriction enzyme鈥, Centre of Biotechnology, Nehru Science Complex, University of Allahabad, 8.12. 2014
鈥淲as binding of free amino acids an early innovation in the evolution of allostery?鈥, Dr. B.R. Ambedkar Center for Biomedical Research, University of Delhi, 11.12.2014
鈥淲as binding of free amino acids an early innovation in the evolution of allostery?鈥, Centre for Computational Biology and Bioinformatics, School of Computational and Integrative Sciences, Jawaharlal Nehru University, New Dehli, 12.12.2014 (accommodation for 2 days provided by JNU)
鈥淲as binding of free amino acids an early innovation in the evolution of allostery?鈥 Global Perspectives on the Structure and Dynamics of聽Liquids and Mixtures: Experiment and Simulation, EMLG 鈥 JMLG annual meeting 2013, 9 鈥 13 September 2013, Lille, France (invited lecture)
鈥淲as binding of free amino acids an early innovation in the evolution of allostery?鈥 Astbury Seminar, University of Leeds, UK, 14th November 2013 (invited seminar).
鈥淐harybdotoxin unbinding from the mKv1.3potassium channel: A Combined computational and experimental study鈥, Modeling interactions in Biolomolecules VI, 2013 at Marianske Lazne, Czech Republic (invited plenary lecture)
鈥淔unctional coupling of DNA duplex聽translocation to its cleavage in a type I restriction enzyme.鈥2nd World DNA and Genome Day-2011, Dalian, China, 25-29.4.2011 (invited lecture)
鈥濿as binding of free amino acids an early innovation in the evolution of allostery?鈥, 8thDiscussions in Structural Molecular Biology, Nove Hrady, 18鈥20.3.2010 (invited plenary lecture)
鈥濻tructural and thermodynamic evidence for allosteric relaxed-state聽symmetry鈥,Hofmeisterfest, October 13 鈥 16 聽2010 Prague, Czech Republic (invited plenary lecture)
Molecular mechanism of allostery in hexameric E. coli arginine repressor, Modeling interactions in Biolomolecules IV, 2009 at Hrub谩 Sk谩la, Czech Republic (invited plenary lecture)
DNA translocation by type I restriction-modification enzymes, 7th International Life Science Meeting, Krems, Austria, 2009 (invited plenary lecture)
Coupling of endonuclease and translocase functions in Type I restriction-modification complexes, National Institute of Health, Bethesda, Maryland, USA, 2009
Young Scientist Invited Talk, Structure of the motor subunit and model for translocation by the type I restriction enzyme EcoR124I, 22ndAnnual Symposium of the Protein Society, 2008, San Diego, California, USA
Structure of the motor subunit and translocation model for EcoR124I restriction-modification complex, 2008, Princeton University, New Jersey, USA
Structure, Function and Dynamics of fungal beta-N-Hexosaminidase, MOLECULAR LIFE SCIENCES 2007, Fall meeting of the GBM, Hamburg
Vibrational spectroscopy and computer modelling of proteins 鈥 building of interdisciplinary bridges. Biological Sciences, University of Calgary, June 2004, Canada.
Foreign research stays
February 1999, Martin Luther Universit盲t, Halle-Wittenberg, Germany, group of assoc. Prof. W. Brandt, Homology modelling of the haptoglobin heavy chain using COMPOSER and SYBYL, supported by the Volkswagen Foundation
December 1999 鈥 April 2001, several short-term stays (altogether 10 weeks), Justus Liebig Universit盲t, Giessen, Germany, group of Prof. W. Schoner, Molecular modelling of the large cytoplasmic loop of Na/K-ATPase, supported by the German and Czech governments
May 2000, Univerzita Komensk茅ho, Bratislava, Slovakia, group of Dr. P. Kvasni膷ka, Fold recognition on P-type ATPases
August 2000, Justus Liebig Universit盲t, Giessen, Germany, group of Dr. B. Boschek, Electron microscopy of chaperone-substrate complexes
March 2001, Justus Liebig Universit盲t, Giessen, Germany, group of Dr. B. Boschek, Electron microscopy of hemoglobin-haptoglobin complexes
May 2001, Universita Degli Studi, Ancona, Italy, group of Prof. L. Mazzanti, Bioinformatics
June 2004, University of Calgary, group of Prof. P. Tieleman, Molecular dynamics of membrane proteins
April 2008, Princeton University, Chemistry department, group of Prof. J. Carey, Structure of the motor subunit and translocation model for EcoR124I restriction-modification complex
April 2009, Princeton University, Chemistry department, group of Prof. J. Carey, Interaction of photosystem proteins PsbP and PsbQ
February 2010, Princeton University, Chemistry department, group of Prof. J. Carey, Allostery in Argine repressor from e. coli.
November 2011, Princeton University, Chemistry department, group of Prof. J. Carey, Apo/holo WrbA simulations
Sept/Oct 2012, Princeton University, Chemistry department, group of Prof. J. Carey, Umbrella sampling in ArgR
February 2015, NOVA Southeastern University, Florida, USA, College of Medical Sciences, group of Prof. K.V. Venkatachalam
March 2016, NOVA Southeastern University, Florida, USA, College of Medical Sciences, group of Prof. K.V. Venkatachalam
Sept 2016- April 2017, NOVA Southeastern University, Florida, USA, College of Ostheopathic Medicine and College of Medical Sciences, Fulbright-Masaryk Scholar (Host: Dr. Cecilia Rokusek)
Seminar lectures given at universities or research institutes
Medical University Graz, Austria, February 8, 2018 (invited seminar on 鈥淢odulation of human ORAI1 channels: modeling and simulations鈥)
Larkin University, College of Pharmacy, Miami, Florida, October 10, 2017 (invited seminar on 鈥淯sing Computational Modeling and Simulation in Understanding Gene Mutations鈥)
Barry University, Department of Chemistry, Miami Shores, Florida, March 22, 2017 (invited seminar on 鈥淯sing Computational Modeling and Simulation in Understanding Protein Structure and Function鈥)
College of Medical Sciences, Nova Southeastern University, Ft. Lauderdale, Florida, February 17th, 2017(invited seminar)
College of Osteopathic Medicine, Nova Southeastern University, Ft. Lauderdale, Florida, November 11th, 2016 (COM Grand round)
College of Osteopathic Medicine, Nova Southeastern University, Ft. Lauderdale, Florida, February 16th, 2015 (invited seminar)
Biomolecular Science Institute, Florida International University, Miami, Florida, February 19th, 2015 (invited seminar)
School of Biosciences, University of Kent, UK, October 2015 (invited seminar)
Physics Department, Astbury Center, Leeds University, Leeds, UK, November 2013 (invited seminar)
Comenius University, November 2013, Bratislava, Slovakia (invited seminar talk, paid by Comenius University)
IZMB, Bonn University Germany 25.1.2012 (invited seminar)
Joint seminar of Fukuoka University and Kyushu University, sponsored by the Japanese Society for Physical Chemistry, Fukuoka, Japan 2.5.2011 (invited seminar)
Biochemistry Department, Lund University, Lund, Sweden 29.7.2011 (invited seminar) Molecular Biology Department, Princeton University, NJ, USA 17.11.2011 (invited seminar)
Chemistry Department, Princeton University, NJ, USA, 16.2.2010 (invited seminar)
La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA 2.8.2010 (invited seminar)
Department of Chemical and Biochemical Engineering, University of Vanderbilt University, Nashville, TN, USA, 10.8.2010 (invited seminar)
Max Planck Institute for Mathmatics, Leipzig, Germany, 29.10.2010 (invited seminar)
National Institute of Health, Bethesda, Maryland, USA, 15.April 2009 (invited seminar talk, paid by NIDDK NIH)
Jagellonian University, 3.11.2009, Krakow, Polska (invited seminar , paid by Jagellonian University)
National Institute of Child Health and Human Development, National Institutes of Health, 15 th April 2008, Bethesda, Maryland, USA (Accomodation covered by NIH)
Princeton University, New Jersey, USA, 21st April 2008 (Accomodation and local expenses covered by Princeton University)
Biological Sciences, University of Calgary, June 2004, Canada.
Awards, Honors, and Editorial Activities
2002, Financial support for research from Sigma-Aldrich awarded for second-place finish in competition for young scientists
2005, Czech television presented a short segment on my research
2006, Otto Wichterle award for excellent young scientist, Academy of Sciences of the Czech Republic
2010, nominated by the Chemistry Department at Princeton University as a Princeton Global Scholar
2016, Fulbright-Masaryk Scholarship 鈥 senior category (2016)
Research grant awards (amounts are approximate after conversion to USD)
2017-2019 Ministry of Education, Science and Sports, LT-Inter Excellence, Strcuture and Function of Cation Tranlocating Systems, Total Award: 100,000 USD. Principal investigator Ettrich
2013-2018 Czech Science Foundation, Symmetric Allosteric Mechanism of Hexameric Escherichia coli Arginine Repressor using Computational Simulations, Total Award: 225,000 USD. Principal investigator Ettrich.
2012-2018 Czech Science Foundation, Cleavage and translocation by Type I restriction-modification complexes, Total Award: 879,600 USD. Principal investigator Ettrich.
2011-2014 Czech Science Foundation, Thiazolinov茅 inhibitory 脽-N-acetylhexosaminidas zalo啪en茅 na nov媒ch, nep艡irozen媒ch substr谩tech Total Award: 116,000 USD. Co-Principal investigator Ettrich.
2010-2016Czech Science Foundation, Structural insight into E. coli protein WrbA, the founding member of a family of proteins implicated in defense of cells against oxidative stress, Total Award: 405,400 USD. Principal investigator Ettrich.
2009-2013 Grant Agency of the Czech Republic, Specific ion effects of proteins in solution and similar relevant biological systems, Total Award: 171,667 USD; 50,000 USD to co-principal investigator Ettrich.
2006-2010 Ministry of Education, Science and Sports, Research center grant, Centre of biocatalysis and biotransformation, Total Award: approximately 3M USD (600,000 USD/year), 800,000 USD total (160,000 USD/year) to Ettrich, principal investigator at ISBE ASCR.
2003-2006 Grant Agency of the Czech Republic, Study of the oxygen evolving complex of photosystem II by molecular modeling and vibrational spectroscopy, Total Award: 70,000 USD. Principal investigator Ettrich.
2004-2005 Ministry of Education, Science and Sports, Aktion Austria-Czech Republic, NMR investigations of recombinant PsbH protein in Escherichia coli, Total award: 40,000 USD. Principal investigator Ettrich.
2005-2007 Grant Agency of the Czech Republic, a-N Acetylgalactosaminidase and a-galactosidase 鈥 structural and functional characterization, its aplication in synthesis of biological active glycoconjugates, Total Award: 50,000 USD to Co-Principal Investigator Ettrich.
Large institutional network grants:
2016-2019 Ministry of Education, Youth and Sports of the Czech Republic, LM 鈥 Large RDI infrastructures projects: LM2015055 鈥 Center for Systems Biology, Coordinator and Principal Investigator
2012-2015FP7:INFRA-2012-2.2.4. 鈥 ISBE 鈥 Infrastructure for Systems Biology-Europe-preparatory phase, Delegate on behalf of the Czech Republic and steering committee member
2005-2012Ministry of Education, Youth and Sports of the Czech Republic, Physical Biology 鈥 new approach in biological research, Total Award: 560,000 USD (80,000 USD/year) to Ettrich. Principal investigator F.Vacha.
2005-2012 Academy of Sciences of the Czech Republic, Institutional research concept: Spatial and functional dynamics of biological, ecological and socio-ecological systems, Total Award: 0.6M USD (100,000 USD/year) to Ettrich. Principal investigator Institute of Systems Biology and Ecology.
Bi- or multilateral grants:
2016-2019 INTERREG V-A: ATCZ14 鈥 Czech-Austrian Center for Supracellular Medical Research (CAC-SuMeR)
2015-2019 COST Action BM1406: Ion Channels and Immune Response toward a global understanding of immune cell physiology and for new therapeutic approaches (IONCHAN-IMMUNRESPON)
2016-2020 COST Action CA15110 Harmonising standardisation strategies to increase efficiency and competitiveness of European life-science research (CHARME)
2011-2012聽Aktion Austria-Czech Republic (No. 60p21) Study of photosynthetic PsbI protein鈥檚 interaction with the thylakoid membrane
2011聽HPC-Europa2 Transnational Access programme, joint grant with Groningen University to gain access to the pan-european infratructure on high performance computing cluster for 2011
2004-2005聽Aktion Austria-Czech Republic (No. 40p2) NMR investigations of recombinant PsbH protein in Escherichia Coli.
2006-2007聽WTZ A/CZ 20-6-06-14, Optimization of Expression and Isotope Enrichment od Photosynthetic Proteins for NMR, Czech Republic-Austria
Editorial Activities
Editorial Board Member, PeerJ
Reviewer for PLOS Computational Biology, Journal of Physical Chemistry B, Proteins: Structure, Function & Bioinformatics, European Biophysics Journal, Chemical Biology & Drug Design, Journal of Biolmolecular Structure & Dynamics, Nucleic Acid Research, Journal of Molecular Modeling,Chemistry Central Journal, Collection of Czechoslovak Chemical Communications, Biologia Plantarum, Materials Structure, Ceskoslovensky casopis pro fyziku
Service in advisory councils and committees
Reviewer/Evaluator for the Southern Association of Colleges and Schools Commission on Colleges (SACSCOC)
Member of the International Evaluation Panel of Palacky University, Faculty of Medicine. (2023).
Chair of the International Evaluation Panel of Masaryk University, Faculty of Pharmacy. (2022).
Chair of the International Evaluation Panel appointed by the Ministry of Youth and Education of the Czech Republic and the rector of the University to chair the external evaluation of the University of Veterinary and Pharmaceutical University Brno (2020).
External foreign expert in the Technical Review Panel (TRP) formed by the Department of Bio-sciences, COMSATS University Islamabad (Pakistan), 2018 and 2021 review of promotion dossiers of faculty
Elected member of the general assembly of the Academy of Sciences of the Czech Republic (since 2010, elected until 2018)
Member of the scientific councils of: Global Change Research Center (former Institute of Systems Biology and Ecology, Academy of Sciences (2007-2015); Institute of Microbiology, Academy of Sciences (2007-2015); Institute of Physical Biology, University of South Bohemia (until 2011); Czech Center of Excellence for Fluorescence Spectroscopy (2006- 2011) and Czech Center of Excellence for Biocatalysis and Biotransformation (2006 -2011)
Member of the educational board of the Faculty of Sciences (2011-2018) and the Institute of Physical Biology (until 2011), University of South Bohemia, Ceske Budejovice
Member of the grant review panel of ERAnet Neuron (2009 and 2012)
Member of the steering committee of the European Infrastructure for Systems Biology ESFRI-ISBE that connects approx. 50 research centers in Europe in the field of Systems Biology (2009-2018)
Member of the steering committee of the regional science infrastructure Upper Austria-South Bohemia (current)
Member of the grant review panel 207 (biochemical reactions) of the Czech Science Foundation 2011-2012
